Table 1.
Baseline demographic, PTSD#, and drinking characteristics of alcohol abstainers vs. non-abstainers over the course of a 12-week clinical trial of prazosin for veterans with PTSD# and comorbid alcohol dependence.
| Variables | Abstainers | Non-abstainers | χ2 | p |
|---|---|---|---|---|
| Demographic (n, %) | ||||
| Age | 0.95 | 0.62 | ||
| 21-29 | 11 (50.0) | 11 (50.0) | ||
| 30-44 | 8 (38.1) | 13 (61.9) | ||
| 45+ | 20 (38.5) | 32 (61.5) | ||
| Gender | 0.21 | 0.65 | ||
| Male | 36 (40.4) | 53 (59.6) | ||
| Female | 3 (50.0) | 3 (50.0) | ||
| Ethnicity | 5.43 | 0.07 | ||
| Caucasian | 35 (44.9) | 43 (55.1) | ||
| African American | 2 (14.3) | 12 (85.7) | ||
| Other | 2 (66.7) | 1 (33.3) | ||
| Marital status | 0.76 | 0.86 | ||
| Single | 12 (41.4) | 17 (58.6) | ||
| Married/cohabitating/partner | 7 (33.3) | 14 (66.7) | ||
| Separated/divorced | 19 (44.2) | 24 (55.8) | ||
| Widowed | 1 (50.0) | 1 (50.0) | ||
| Medication condition | 1.25 | 0.26 | ||
| Prazosin | 23 (46.0) | 27 (54.0) | ||
| Placebo | 16 (34.8) | 30 (65.2) | ||
| PTSD# and drinking (mean, SD#) | ||||
| CAPS# | ||||
| Severity of PTSD# symptoms | 74.28 (20.64) | 73.30 (15.75) | 47.55 | 0.65 |
| Avoidance | 30.44 (8.62) | 30.44 (8.04) | 29.99 | 0.36 |
| Reexperience | 22.44 (8.42) | 18.84 (6.97) | 32.41 | 0.30 |
| Hyperarousal | 21.41 (7.21) | 23.69 (6.38) | 23.67 | 0.65 |
| Alcohol consumption | ||||
| Number of drinking days (over 90 days) | 42.38 (30.17) | 47.11 (27.95) | 54.34 | 0.42 |
| Number of heavy drinking days (over 90 days) | 39.05 (29.67) | 41.43 (28.19) | 55.55 | 0.45 |
| Number of drinks per drinking day | 22.54 (12.25) | 17.30 (11.66) | 94.00 | 0.42 |
| Percent drinking days | 43.39 (32.97) | 46.03 (31.32) | 55.55 | 0.45 |
Note:
#
PTSD=posttraumatic stress disorder, SD=standard deviation, CAPS=clinician administered PTSD scale; chi-square comparisons across group (abstainers vs. non-abstainers) revealed no significant differences in baseline demographic, PTSD, or drinking characteristics.