Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 1;21(5):1173–1180. doi: 10.1038/s41436-018-0311-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Subclinical atherosclerotic cardiovascular disease in FH-associated variant carriers. Coronary artery calcium (CAC) scores of familial hypercholesterolemia (FH)-associated variant carriers with subclinical disease and CAC >0. (n = 19) (filled colored circles) in comparison with the distribution of CAC scores in the Multi-Ethnic Study of Atherosclerosis (MESA) subcohort of Caucasian ethnicity and without symptomatic clinical atherosclerotic cardiovascular disease (ASCVD) and treated diabetes. The rectangles represent the expected CAC score distribution between the 25th and 75th percentile in the MESA subcohort for every age and for men (blue) and women (red) separately, with age on the x-axis and CAC score on the y-axis. While 16 individuals were not expected to have subclinical ASCVD, three individuals did (indicated with black circles). However, the 61-year-old female with LDLR p.Gly396Ala and the 54-year-old female with APOB p.Arg3527Gln displayed plaques in carotid arteries. The 59-year-old male harbored LDLR p.Arg115Cys.