Table 2:

Previous reports of clozapine re-challenge with published re-titration rates and reported outcome

Report	Lowest reported ANC (in cells/mm3) on first clozapine challenge	Time between clozapine interruption and rechallenge	Rate at re-challenge	Lowest reported ANC (in cells/mm3) after rechallenge	Additional notes
Rechallenge After Neutropenia
Eseonu et al. 2010	Only reported to have previous episode of neutropenia	>2 years	Day 1: 12.5mg, Day 2: 25mg Day3 on wards; titrated at 25mg daily increments until reaching 325mg	No reported trough value. Starting ANC was 4100 cells/mm3. No recurrence of neutropenia reported.	Patient was on olanzapine 30mg/day and started on lithium 300mg/day 1 week prior to clozapine initiation. Once clozapine dose of 325mg/day was reached olanzapine was tapered to discontinuation.
Ghaznavi et al. 2008	900	2 years	Day 1:12.5 mg, Day 2: 12.5mg BID, Day 3 onwards: titrated at 25mg increments daily to 300mg eventually discharged with a dose of 325mg	5400	After initial clozapine failure the patient was rechallenged within 1 week and re-experienced neutropenia with a nadir ANC of 850 cells/mm3. On final, and successful, rechallenge patient was concurrently treated with lithium 300mg daily.
Huguet et al. 2013	Unclear	unclear	Started at 25mg and increased by 25mg every three days to a dose of 300mg	1800	Patient with neutropenia and three previous failures. Last, and successful, attempt was with concurrent filgrastim 0.3 mg twice weekly.
Jauss et al. 2000	<1000	4 days	Day 1 and 2: 25mg, Day 3 onwards: 50mg	~3500	Patient stable on a combination of clozapine, levodopa, and metixen.
Wu et al. 2008	880	21 days	Day 1: 25mg Day 5: 50mg, Day 9: 75mg, Day 12: 100mg, Day 16: 150mg	WBC ~6000 (No ANC)	Did not report ANC values on re-challenge. Preceding clozapine re-challenge patient was started on olanzapine 10mg, which was suspected of prolonging neutropenia.
Rechallenge After Agranulocytosis
Hazewinkel et al. 2013	Only reported to have had a previous episode of agranulocytosis	4 years	Day1: 12.5, Day 3: 25mg, Day12: 50mg, Day 15: 75 mg, Day 19: 100mg, Day 23: 150mg, Day 26: 200mg, Day 36: 300mg	<100	During titration patient was treated with G-CSF at a roughly weekly basis, escalating to daily treatments in the context of worsening neutropenia.
Small et al. 2005	WBC 1800+ granulocyte 11% (~200)	Not indicated	25mg every 3–4 days until 800mg	WBC of 4500 + granulocyte 48% (~2200)	At some point during titration patient was started on lithium (unknown dose).