Table 4:
Risks of ischemic placental disease in fresh cycles in the setting of high estradiol levels (>90th percentile, or 3515 (pg/mL))
| High estradiol n=156 |
Normal estradiol n=1406 |
|
|---|---|---|
| Small for gestational age < 10th percentile | ||
| Ischemic placental disease or IUFD | 52 (33.3) | 367 (26.1) |
| Crude RR (95% CI) | 1.3 (1.0-1.6) | 1.0 |
| Adjusted RR (95% CI)a | 1.3 (0.97-1.6) | 1.0 |
| Preeclampsia | 11 (7.1) | 108 (7.7) |
| Crude RR (95% CI) | 0.92 (0.51-1.7) | 1.0 |
| Adjusted RR (95% CI)a | 0.73 (0.38-1.4) | 1.0 |
| Placental abruption | 7 (4.5) | 42 (3.0) |
| Crude RR (95% CI) | 1.5 (0.69-3.2) | 1.0 |
| Adjusted RR (95% CI)a | 2.0 (0.86-4.5) | 1.0 |
| Small for gestational age | 36 (23.1) | 271 (19.3) |
| Crude RR (95% CI) | 1.2 (0.88-1.6) | 1.0 |
| Adjusted RR (95% CI)b | 1.2 (0.88-1.6) | 1.0 |
| Small for gestational age < 3rd percentile | ||
| Ischemic placental disease or IUFD | 31 (19.9) | 214 (15.2) |
| Crude RR (95% CI) | 1.3 (0.93-1.8) | 1.0 |
| Adjusted RR (95% CI)b | 1.3 (0.91-1.8) | 1.0 |
| Small for gestational age | 14 (9.0) | 79 (5.6) |
| Crude RR (95% CI) | 1.6 (0.93-2.7) | 1.0 |
| Adjusted RR (95% CI)b | 1.7 (0.96-2.9) | 1.0 |
IUFD: intrauterine fetal demise
Data presented as n (%) or risk ratio (RR) and 95% confidence interval (CI)
a
Adjusted for maternal age and year of delivery
b
Adjusted for maternal age