Figure.

Computed tomography findings of the brain metastasis. a) Relapse of brain metastasis and carcinomatous meningitis. Whole-brain radiation therapy (WBRT) was initiated. b) One month after performing WBRT and just prior to crizotinib initiation, progression of the metastatic lesion was observed. A cytological analysis of the cerebrospinal fluid (CSF) was positive for malignant cells. c) One month after crizotinib initiation, the response of the metastatic lesion was observed. A cytological analysis of the CSF was negative for malignant cells. d) One month after withdrawal of crizotinib, no remarkable change was observed.