Table.

Crizotinib and Alectinib Concentrations in the CSF and Plasma.

		Reference		CSF		Plasma		CSF/plasma		WBRT
Crizotinib (ng/mL)		3		0.616		237		0.003		+
		4		0.35		587		0.0006		-
				0.80		800		0.001		+
		Our case		4.32		158		0.026		+
Alectinib (nmol/L)		5		2.69		3.12		0.86

CSF: cerebrospinal fluid, WBRT: whole-brain radiation therapy