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. 2019 Mar 14;41:497–508. doi: 10.1016/j.ebiom.2019.02.055

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Inhibition of the STING signaling protects against CLP-induced intestinal injury. (A) Representative images of H&E, c-caspase3, and TUNEL staining in WT and STING-KO mice after CLP treatment. (B, C, D) MPO activity and inflammatory cytokines within intestinal mucosa. (E) Proteins levels of ZO-1 and occludin in intestinal tissue were assessed by western blot. (F, G) Localization of ZO-1 and occludin within intestinal mucosa evaluated by immunofluorescence after CLP. Data are expressed as the mean ± SD. ^⁎P < .05 vs sham group; ^#P < .05 vs CLP group. n = 6 mice per group.