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. 2019 Apr 1;8(4):24. doi: 10.1038/s41389-019-0133-3

Fig. 2. Restoration of p53 in orthotopically transplanted lung adenocarcinomas causes an infiltration of CD45pos. immune cells and fibroblasts and elevated chemokine levels.

Fig. 2

a Histological sections from Control and p53-Restored tumors at Day 2, 6, and Day 10. H&E and IHC for GFP, CD45, and SMA. b Multiparameter cytokine detection in bronchioalveolar lavage (BAL) of Control and p53-Restored mice. Significantly changing cytokines as determined by t-test are indicated (IL-6, CCL2, CXCL1, M-CSF, and CCL4). c Multiparameter cytokine detection in KPrLG cell culture supernatant after p53 restoration in vitro