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. 2019 Apr 1;9:5407. doi: 10.1038/s41598-019-41900-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of sHLA-G levels of EOC patients and healthy donors. (A) sHLA-G is significantly (p < 0.0001) elevated in EOC compared to healthy donors (HD). (B) Elevated sHLA-G levels in EOC are independent of a specific HLA-G 3′UTR haplotype. Bars indicate mean value ± SEM. (C) sHLA-G levels increase with ascending FIGO stage in EOC patients without reaching significance. sHLA-G levels are given in ng/ml. Statistic was performed by Mann-Whitney test (A,C), or Kruskal-Wallis with Dunn’s test for multiple comparison (B). n.s. not significant, n.t. not tested due to low numbers.