Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 26;10:602. doi: 10.3389/fmicb.2019.00602

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Shih, Liao, Tseng, Deng and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The GCN5 histone acetyltransferase gene is required for resistance to chitosan and cell surface-disrupting agents, and GCN5 expression is inhibited by chitosan. (A) gcn5Δ strains were highly sensitive to chitosan. Additionally, the growth of gcn5Δ cells was significantly inhibited by the cell wall stress agents calcofluor white and caspofungin and by (B) the cell membrane-disturbing agent SDS. The wild-type SC5314 strain and the complemented strain exhibited similar growth. (C) Chitosan treatment of SC5314 cells for 20 min significantly repressed GCN5 expression. The values are the means ± SDs of at least three experimental replicates. ^∗P < 0.05 compared with the value for untreated wild-type SC5314 cells. The expression values were normalized to the expression of the ACT1 gene as indicated. Statistical significance was determined using Student’s t-test.