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. 2019 Mar 26;10:283. doi: 10.3389/fphar.2019.00283

FIGURE 1.

FIGURE 1

Effects of UFP-512 on the mechanical allodynia and thermal hyperalgesia induced by CFA. The effects of acute intraperitoneal administration of different doses (logarithmic axis) of UFP-512 on the mechanical allodynia (A) and thermal hyperalgesia (B) induced by CFA in ipsilateral (continuous lines) and contralateral hind paws (discontinuous lines) are shown. UFP-512 was administered 1 h before testing. In both panels and for each dose assessed, ∗ indicates significant differences vs. their respective effects in the contralateral paw, + indicates significant differences vs. the effect produced by 1 mg/kg of UFP-512 in the ipsilateral paw and # indicates significant differences vs. the effect produced by 3 mg/kg of UFP-512 in the ipsilateral paw (P < 0.05; one-way ANOVA, followed by the Student–Newman–Keuls test). In both tests, data are expressed as mean values of maximal possible effect (%) ± SEM; n = 6 animals per dose.