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. 2019 Mar 26;10:283. doi: 10.3389/fphar.2019.00283

FIGURE 2.

FIGURE 2

Effects of UFP-512 on the mechanical allodynia, thermal hyperalgesia, and thermal allodynia induced by CCI. The effects of the intraperitoneal acute administration of different doses (logarithmic axis) of UFP-512 on the mechanical allodynia (A), thermal hyperalgesia (B), and thermal allodynia (C) induced by sciatic nerve injury in the ipsilateral hind paw of CCI-injured (continuous lines) or sham-operated mice (discontinuous lines) are represented. UFP-512 was administered 1 h before testing. For each test and dose evaluated, ∗ indicates significant differences vs. their respective effects in sham-operated mice, + indicates significant differences vs. the effects produced by 1 mg/kg of UFP-512 in CCI-injured mice, and # indicates significant differences vs. the effects produced by 3 mg/kg of UFP-512 in CCI-injured mice (P < 0.05; one-way ANOVA, followed by the Student–Newman–Keuls test). Data are expressed as mean values of maximal possible effect (%) for mechanical allodynia and thermal hyperalgesia, and inhibition (%) for thermal allodynia ± SEM; n = 6 animals per dose.