FIGURE 8.

Effects of the coadministration of UFP-512 with SFN on the mechanical allodynia and thermal hyperalgesia induced by peripheral inflammation or sciatic nerve injury. Mechanical antiallodynic and thermal antihyperalgesic effects produced by 10 mg/kg SFN and 1 mg/kg UFP-512 intraperitoneally administered alone or combined in animals with inflammatory (A, C) or neuropathic pain (B, D) are shown. SFN and UFP-512 were administered at 3 and 1 h before testing, respectively. For each test, ^∗ indicates significant differences vs. its respective animals treated with vehicle plus saline, ⁺ indicates significant differences vs. its respective animals treated with vehicle plus UFP-512, and ^# indicates significant differences vs. its respective animals treated with SFN plus saline (P < 0.05, one-way ANOVA, followed by the Student–Newman–Keuls test). Data are expressed as mean values of maximal possible effect (%) for mechanical allodynia and thermal hyperalgesia ± SEM; n = 6 animals per group.