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. 2019 Mar 26;10:283. doi: 10.3389/fphar.2019.00283

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Copyright © 2019 Polo, Díaz, Gallardo, Leánez, Balboni and Pol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of UFP-512 on the depressive-like behaviors associated with neuropathic pain. Immobility time in seconds (s) for CCI-injured and sham-operated mice treated with 1 mg/kg of UFP-512 or saline evaluated at 28 days after surgery in TST are represented. UFP-512 was administered 1 h before testing. In all groups, ^∗ indicates significant differences vs. sham-operated mice treated with saline and ⁺ indicates significant differences vs. CCI-injured mice treated with saline (P < 0.05, one-way ANOVA, followed by the Student–Newman–Keuls test). Results are expressed as mean ± SEM; n = 8 animals for each experimental group.