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. 2019 Apr 1;10:1463. doi: 10.1038/s41467-019-09375-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Myeloid-specific truncated retinoid X receptor α expression is necessary for signal transducer and activator of transcription factor 3 activation and colorectal carcinogenesis. a Tumor size from mice treated with azoxymethane (AOM)/dextran sodium sulfate (DSS) for 4 months. Each dot represents a tumor. Data are mean ± SD (n = 6), one-way analysis of variance (ANOVA). b Tumor size distribution. Data are mean ± SEM (n = 6), two-way ANOVA. c Colon tumor sections from mice treated with AOM/DSS for 4 months were stained with hematoxylin and eosin, Scale bars, 100 μm, and classified into normal, low-grade, and high-grade lesions based on histological analysis (n = 6). Data are mean ± SEM (n = 6), two-way ANOVA. d Representative CD68 immunostaining image of colonic sections from mice treated with AOM/DSS (scale bars, 50 μm) and the score of the number of CD68-positve cells per field. Each dot represents a mouse, and 10 fields were counted per mouse. Data are mean ± SD (n = 6), one-way ANOVA. e Relative mRNA expression levels of the indicated genes in colon of mice treated with AOM/DSS were determined by quantitative reverse transcriptase–PCR. Data are mean ± SEM (n ≥ 4). one-way ANOVA. f Colon lysates from mice treated with AOM/DSS were analyzed by immunoblotting. The bands are quantified with Image J and normalized to β-actin. One of three similar experiments is shown. *P < 0.05, **P < 0.01, ***P < 0.001