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. 2019 Mar 26;10:235. doi: 10.3389/fneur.2019.00235

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Copyright © 2019 Mu, Bakreen, Juntunen, Korhonen, Oinonen, Cui, Myllyniemi, Zhao, Miettinen and Jolkkonen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of perilesional angiogenesis. Definition of perilesional cortex 200 μm from the border of ischemic core (A). Representative RECA-1 staining with thionin counterstaining in sham-operated (B), and MCAO (C) rats. Stereological analysis showed ischemia-induced increase in blood vessel density in perilesional cortex (D). Scale 1 mm (A), 50 μm (B,C). Statistical significance: ^*P < 0.05 (compared to SHAM+V+S). SHAM, sham-operated; MCAO, middle cerebral artery occlusion; V, 2 d vehicle; C, 2 d cell infusion; S, standard housing; EE, enriched environment.