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. 2019 Mar 26;10:235. doi: 10.3389/fneur.2019.00235

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Copyright © 2019 Mu, Bakreen, Juntunen, Korhonen, Oinonen, Cui, Myllyniemi, Zhao, Miettinen and Jolkkonen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of perilesional gliosis. Representative staining of GFAP-stained sections from a sham-operated rat (A) and an MCAO rat (B). Stereological analysis revealed an ischemia-induced increase in the number of glial cells in the perilesional cortex (C). Glial scar volume did not differ between the MCAO groups (D). Scale 50 μm. Statistical significance: ^***P < 0.001 (compared to SHAM+V+S). SHAM, sham-operated; MCAO, middle cerebral artery occlusion; V, 2 d vehicle; C, 2 d cell infusion; S, standard housing; EE, enriched environment.