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. 2019 Feb 15;9(4):643–652. doi: 10.1002/2211-5463.12598

Figure 3.

Figure 3

Effects of Tofo on the histological changes and the deposition of fatty tissue in the liver of medaka NASH model. Representative microscopic findings of medaka liver tissues stained with HE. (A) Chow‐diet‐fed medaka. (B) Medaka fed with HFD and HFD + Tofo for 4, 8, and 12 weeks. The insets in HFD for 8 and 12 weeks indicate the inflammatory cells and ballooning degeneration of the hepatocyte, respectively. Black arrows indicate fat deposition areas. Scale bar represents 100 μm. (C) Quantitative analysis of fat deposition areas in the medaka liver. The values represent mean ± SD (n = 15 for each group). *P < 0.05, and N.S., no statistical significance. Student's t‐test.