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. 2019 Mar 26;11:8. doi: 10.3389/fnsyn.2019.00008

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Copyright © 2019 MacDougall and Fine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subtractive analysis of unitary EPSP as an estimate of quantal size. (A) EPSCaT amplitudes (above) and EPSP amplitudes (below) recorded before and after long-term potentiation (LTP) induction. Corresponding EPSP and EPSCaT amplitudes are color-coded on the basis of EPSCaTs, with successes in red and failures in black. (B) Mean EPSP traces corresponding to EPSCaT successes (red) and failures (black). The difference between these averages (Subtraction, green) represents the mean contribution to the EPSP (i.e., the unitary EPSP) from the imaged active synapse. Traces shown are means before (Baseline; left) and 20–60 min after (right) LTP induction. LTP results in large increases in the overall mean EPSP and pr at the imaged synapse. The unitary EPSP amplitude from this imaged synapse, however, does not significantly change. (C) Values of compound EPSP, pr, EPSPs grouped according to success (S) or failure (F), and unitary EPSP amplitude from the imaged synapse. As revealed by such subtractive analysis, LTP induction in these experiments led to significant and corresponding increases in pr at the imaged synapse and in the (multi-synaptic) EPSP, with no significant change in the unitary EPSP from the imaged synapse. Figure adapted from Enoki et al. (2009).