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. 2019 Mar 26;11:8. doi: 10.3389/fnsyn.2019.00008

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Copyright © 2019 MacDougall and Fine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Minimal stimulation and optical quantal analysis. (A) Representative sequential traces showing the perfect correspondence between success or failure of EPSCaTs (left) and EPSPs (right) before (Baseline) and After LTP. This constant correspondence provides strong evidence that the stimulus in this experiment activated only the imaged synapse and that EPSCaTs are reliable reporters of transmitter release. (B) EPSCaT (above) and EPSP amplitudes (below) recorded from this synapse before and after LTP induction. LTP induction increased pr but not the unitary EPSP amplitude. (C) Values of pr (left) and unitary EPSP (right) from the imaged synapse for this and two other experiments (black) are shown before and after LTP (weighted means shown in blue). Such optically confirmed minimal stimulation demonstrates that LTP induction leads to significant increases in pr, with no significant change in unitary EPSP amplitude. Figure adapted from Enoki et al. (2009).