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. 2019 Mar 26;12:69. doi: 10.3389/fnmol.2019.00069

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Copyright © 2019 Jessen and Mirsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main transitions in the Schwann cell lineage. A scheme illustrating key cell types involved in Schwann cell development, and in nerve repair. Also shown are the alternative cells that can develop from Schwann cell precursors (SCP) in addition to immature Schwann cells (iSch). Black uninterrupted arrows: normal developmental transitions. Red arrows: the Schwann cell injury response. Stippled arrows: post-repair formation of myelin and Remak cells (with permission from Jessen et al., 2015b).