Figure 5.

Molecular expression at the main stages of the embryonic Schwann cell lineage. Below the lineage drawing, main cell biological differences between each developmental each stage are indicated. The molecular markers of each stage divide into three groups: (i) markers that are upregulated at the crest/SCP transition, and maintained by iSCh (blue); (ii) markers that are upregulated at the SCP/iSch transition (pink); and (iii) markers that present on neural crest cells and SCP but are downregulated at the SCP/iSch transition (green). For references, see Jessen and Mirsky (2005a) where more detailed comments on gene expression patterns are provided.