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. 2019 Mar 26;9:179. doi: 10.3389/fonc.2019.00179

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Copyright © 2019 Fumarola, Bozza, Castelli, Ferlenghi, Marseglia, Lodola, Bonelli, La Monica, Cretella, Alfieri, Minari, Galetti, Tiseo, Ardizzoni, Mor and Petronini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Chemical formulas of tested compounds. (B) Hypothesized conversion of 3-APA group of UPR1371 in acrylamide of FIIN-2. (C) Putative mechanism of action for acetamide derivatives UPR1372, UPR1373 and UPR1376. The leaving group installed on the acetamide fragment is colored in red.