Table 1.

Characteristics of study population stratified by change in eCRF, relative to sex-, and age-defined median, from HUNT2 to HUNT3 (n = 751).

	Change in eCRF
	Remained low (n = 265)	Decreased (n = 112)	Increased (n = 110)	Remained high (n = 264)
Age at HUNT MRI, mean, SD	60.3 ± 3.88	56.9 ± 3.34	60.8 ± 3.43	57.6 ± 4.15
Women, n (%)	137 (51.7)	59 (52.7)	57 (51.8)	137 (51.9)
University/college, n (%)	70 (26.4)	36 (32.1)	33 (30.0)	110 (41.7)
Smokers (current), n (%)	67 (25.3)	31 (27.7)	29 (26.4)	58 (22.0)
HADS-A change*, n (%)
Remained low	217 (81.9)	86 (76.8)	92 (83.6)	213 (80.7)
Improved	14 (5.3)	12 (10.7)	9 (8.2)	23 (8.7)
Worsened	17 (6.4)	7 (6.3)	3 (2.7)	18 (6.8)
Remained high	17 (6.4)	7 (6.3)	6 (5.5)	10 (3.8)
HADS-D change*, n (%)
Remained low	217 (81.9)	92 (83.0)	100 (90.9)	235 (89.0)
Improved	11 (4.2)	3 (2.7)	6 (5.5)	12 (4.5)
Worsened	25 (9.4)	9 (8.0)	2 (1.8)	14 (5.3)
Remained high	12 (4.5)	7 (6.3)	2 (1.8)	3 (1.1)
HADS-A HUNT2, mean, SD	3.93 ± 3.06	4.35 ± 3.83	3.53 ± 2.93	3.81 ± 2.99
ΔHADS-A**, mean, SD	−0.15 ± 2.99	−0.55 ± 3.41	−0.13 ± 2.52	−0.34 ± 2.92
HADS-D HUNT2, mean, SD	3.56 ± 2.94	3.32 ± 3.26	2.92 ± 2.69	2.67 ± 2.64
ΔHADS-D**, mean, SD	0.03 ± 2.90	−0.11 ± 3.01	0.01 ± 2.19	0.08 ± 2.56
eCRF HUNT2, mean, SD	38.5 ± 5.23	43.9 ± 4.76	40.5 ± 4.66	45.3 ± 5.41
ΔeCRF§, mean, SD	−6.81 ± 2.82	−9.97 ± 2.25	−3.13 ± 2.19	−5.76 ± 2.35

eCRF, estimated cardiorespiratory fitness; HADS-A, Hospital Anxiety and Depression Scale anxiety subscale; HADS-D, Hospital Anxiety and Depression Scale depression subscale.

^*Change in HADS from HUNT2 to HUNT3 based on a cut-off at ≥8 on the HADS-A and HADS-D subscales.

^**Change in HADS calculated by subtracting HADS-scores at HUNT2 from HADS-scores at HUNT3.

^§Change in eCRF calculated by subtracting eCRF at HUNT2 from eCRF at HUNT3.