Table 3.

Docking energies of five best candidates from virtual screening, with Drugbank ID, Docking energies, and affinity ratio.

Drugbank ID	Name	Docking energy on WT M2 channel (kcal/mol)	Docking energy on S31N mutant M2 channel (kcal/mol)	Affinity ratio WT:S31N*
DB00942	Cycrimine	−8.3	−8.3	1
DB01191	Dexfenfluramine	−6.3	−6.0	0.6
DB01170	Guanethidine	−5.9	−5.7	0.71
DB00191	Phentermine	−5.3	−4.8	0.43
DB01577	Methamphetamine	−4.8	−4.5	0.6

^*$Ratio=\frac{K_1}{K_2}=exp\left(\frac{(\Delta G_1-\Delta G_2)}{RT}\right)$.