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. 2019 Mar 26;9:187. doi: 10.3389/fonc.2019.00187

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Copyright © 2019 Eisemann, Costa, Peterziel and Angel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The deletion of Pdpn in myeloid cells improves survival of glioma bearing mice. (A) Schematic representation of genotypes applied for syngeneic transplantations of high-grade glioma cells. (B) Percentage of PDPN⁺ cells (of all CD11b⁺ cells) in mandibular lymph nodes of control and conditional knockout (cKO) animals, assessed by flow cytometry, data represent mean and SD, p = 0.0001; Student's t-test. (C) Immunohistochemical staining of mCherry positive glioma cells implanted in control and cKO brains, scale bar 1 mm and 50 μm for magnifications. (D) Kaplan-Meier survival analysis showed significantly prolonged survival of cKO animals, p = 0.016 (log-rank test); n = 10. *p < 0.05, **p < 0.001.