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. 2019 Apr 1;9:5404. doi: 10.1038/s41598-019-41820-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of CYP3A4*1G and ABCC2 −24C > T polymorphisms on the steady-state mean plasma trough concentrations of lenvatinib. Graphical analysis was performed using a box and whiskers plot. The box spanned data between 2 quartiles (IQR), with the median represented as a bold horizontal line. The ends of the whiskers (vertical lines) represent the smallest and largest values that are not outliers. Outliers (circle) are values between 1.5 and 3 IQRs from the end of the box. Values more than three IQRs from the end of the box are defined as extremes (stars).