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. 2019 Apr 1;9:5404. doi: 10.1038/s41598-019-41820-y

Table 4.

The frequencies of lenvatinib-induced adverse events between genotypes of ABC transporters and CYP3A4/5.

Adverse events Hypertension P value Proteinuria P value Hand-foot syndrome P value
CTCAE grade 0 1 2 3 0 1 2 3 0 1 2
ABCB1 1236C>T
C/C 0 4 3 1 0.140 3 2 3 0 0.599 0 6 2 0.431
C/T 0 3 16 3 11 3 6 2 0 14 8
T/T 0 1 6 3 6 3 1 0 1 7 2
ABCB1 2677G>T/A
G/G 0 0 8 1 0.211 3 2 4 0 0.387 0 7 2 0.702
G/T + G/A 0 4 10 5 11 4 2 2 1 11 7
T/T + T/A + A/A 0 4 7 1 6 2 4 0 0 9 3
ABCB1 3435C>T
C/C 0 3 10 1 0.798 4 3 7 0 0.093 0 13 1 0.150
C/T 0 4 12 5 13 3 3 2 1 11 9
T/T 0 1 3 1 3 2 0 0 0 3 2
ABCG2 421C>A
C/C 0 5 11 4 0.606 11 4 4 1 0.896 0 14 6 0.595
C/A + A/A 0 3 14 3 9 4 6 1 1 13 6
ABCC2 −24C>T
C/C 0 3 17 4 0.305 11 5 7 1 0.866 1 15 8 0.574
C/T + T/T 0 5 8 3 9 3 3 1 0 12 4
CYP3A4 20230G>A( *1G )
*1/*1 0 6 14 4 0.625 14 3 6 1 0.457 1 14 9 0.281
*1/*1G + *1G/*1G 0 2 11 3 6 5 4 1 0 13 3
CYP3A5 6986A>G(*3)
*1/*1 + *1/*3 0 3 9 2 0.923 5 4 4 1 0.577 0 12 2 0.185
*3/*3 0 5 16 5 15 4 6 1 1 15 10

Data are presented as patients numbers.