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. 2019 Apr 2;39(4):BSR20181915. doi: 10.1042/BSR20181915

Table 1. Main characteristics of included studies in our meta-analysis.

Author Year Country Ethnicity Cancer type Control source Genotyping method Number of cases Number of controls HWE
GG GA AA GG GA AA
Zhong 2016 China Asian Colorectal HB PCR-RFLP 85 125 64 152 172 34 Yes
Masaoka 2016 Japan Asian Bladder HB TaqMan 3 38 33 27 265 448 Yes
Liu 2016 China Asian Hepatocellular HB Affymetrix 48 262 283 236 1229 1748 Yes
Kagemoto 2016 Japan Asian Esophageal PB Multiplex PCR 31 36 50 60 389 676 Yes
Chen 2016 China Asian Gastric HB PCR-RFLP 83 117 46 104 125 45 Yes
Ji 2015 Korea Asian Head and neck HB TaqMan 26 107 127 15 125 190 Yes
Hidaka 2015 Japan Asian Gastric PB TaqMan 32 173 252 35 168 254 Yes
Bediaga 2015 Spain Caucasian Head and neck PB TaqMan 78 61 61 203 391 39 1 NA
Ye 2014 China Asian Esophageal HB PCR-RFLP 224 400 377 150 578 663 Yes
Tsai 2014 China Asian Head and neck HB TaqMan 47 165 224 25 221 268 No
Chung 2014 China Asian UADT HB MassARRAY 68 76 108 25 111 125 Yes
Yuan 2013 China Asian Head and neck PB TaqMan 42 180 170 72 362 455 Yes
Wu 2013 China Asian Esophageal PB TaqMan 138 309 355 101 410 510 Yes
Gao 2013 China Asian Esophageal PB TaqMan 252 907 939 199 909 1155 Yes
Dura 2013 Dutch Caucasian Esophageal PB TaqMan 326 20 0 406 23 0 Yes
Crous-Bou 2013 Spain Caucasian Colorectal PB Illumina 457 324 79 513 360 54 Yes
Liang 2012 Island Mixed Head and neck PB TaqMan 530 38 5 593 76 15 No
Gu 2012 China Asian Esophageal HB MassArray 53 168 158 26 170 182 Yes
Ferrari 2012 France Caucasian Colorectal PB TaqMan 1129 97 5 1800 176 6 Yes
Duell 2012 Spain Caucasian Gastric PB Illumina 317 45 2 1133 132 6 Yes
Chiang 2012 China Asian Colorectal HB PCR-RFLP 7 34 62 43 205 297 Yes
Yin 2011 Japan Asian Colorectal PB PCR-RFLP 25 161 268 71 393 588 Yes
Wang 2011 China Asian Esophageal HB PCR-CTPP 15 34 33 17 67 78 Yes
McKay 2011 France Caucasian UADT PB Illumina 6776 4161 4161 7742 9071 907 1 NA
Marichalar-Mendia 2011 Spain Caucasian Head and neck PB TaqMan 80 71 71 203 391 39 1 NA
Ji 2011 Korea Asian Head and neck HB TaqMan 30 87 108 15 112 174 Yes
Hakenewerth 2011 U.S.A. Mixed Head and neck PB Illumina 1192 311 311 1243 791 791 NA
Wei 2010 U.S.A. Caucasian Head and neck HB PCR-RFLP 1059 51 0 1075 52 2 Yes
Tanaka 2010 Japan Asian Esophageal HB Affymetrix 151 5911 5911 44 7761 776 1 NA
Soucek 2010 Czech Caucasian Head and neck HB TaqMan 101 21 0 111 10 1 Yes
Mohelnikova- Duchonova 2010 Czech Caucasian Pancreatic PB TaqMan 213 22 0 242 22 1 Yes
Garcia 2010 Brazil Mixed Head and neck HB PCR-RFLP 195 12 0 213 29 2 Yes
Cao 2010 China Asian Gastric PB DHPLC 40 148 194 29 160 193 Yes
Yang 2009 China Asian Colorectal HB SNPLex 39 181 205 62 319 370 Yes
Oze 2009 Japan Asian UADT HB TaqMan 71 222 292 53 408 709 Yes
Kawase 2009 Japan Asian Breast HB TaqMan 25 162 265 47 322 539 Yes
Kanda 2009 Japan Asian Pancreatic HB TaqMan 4 55 101 74 551 975 Yes
Ding 2009 China Asian Esophageal PB DHPLC 8 75 108 19 96 106 Yes
Cui 2009 Japan Asian Esophageal PB Illumina 194 363 510 151 986 1626 Yes
Akbari 2009 Iran Asian Esophageal PB MassARRAY 21 232 490 73 471 827 Yes
Solomon 2008 India Asian Head and neck HB PCR-RFLP 13 56 57 8 38 54 Yes
Lee 2008 China Asian Esophageal HB PCR-RFLP 117 149 140 46 275 335 Yes
Guo 2008 China Asian Esophageal HB PCR-RFLP 17 25 38 24 168 288 Yes
Gao 2008 China Asian Colorectal PB DHPLC 15 73 102 20 109 93 Yes
Ding 2008 China Asian Hepatocellular PB PCR-RFLP 21 132 54 26 97 84 Yes
Zhang 2007 U.S.A. Caucasian Gastric PB TaqMan 261 31 1 352 48 1 Yes
Yin 2007 Japan Asian Colorectal PB PCR-RFLP 40 294 345 37 289 452 Yes
Yang 2007 China Asian Esophageal PB PCR-CTPP 33 80 78 22 76 100 Yes
Hiraki 2007 Japan Asian Head and neck HB TaqMan 26 75 138 31 213 471 Yes
Asakage 2007 Japan Asian Head and neck PB PCR-RFLP 31 223 388 19 28 49 No
Sakamoto 2006 Japan Asian Hepatocellular HB PCR-CTPP 12 73 124 13 103 159 Yes
Matsuo 2006 Japan Asian Colorectal HB PCR-CTPP 19 102 136 36 259 473 Yes
Hashibe 2006 France Caucasian Head and neck HB TaqMan 719 471 471 877 1081 108 1 NA
Hashibe 2006 France Caucasian Esophageal HB TaqMan 163 41 41 792 951 95 1 NA
Chen 2006 China Asian Esophageal HB PCR-RFLP 88 117 125 39 240 313 Yes
Yang 2005 China Asian Esophageal HB PCR-CTPP 6 85 74 22 168 304 Yes
Wu 2005 China Asian Esophageal PB PCR-RFLP 39 49 46 16 191 130 No
Landi 2005 France Caucasian Colorectal HB Millipore 292 54 2 263 48 3 Yes
Risch 2003 Germany Caucasian Head and neck PB PCR-RFLP 227 18 0 227 24 0 Yes
Chao 2003 China Asian Esophageal HB PCR-RFLP 19 41 28 7 43 55 Yes
Yokoyama 2002 Japan Asian Esophageal PB PCR-RFLP 51 73 110 31 220 383 Yes
Boonyaphiphat 2002 Thailand Asian Esophageal HB APLP 15 86 101 28 139 94 No
Yokoyama 2001 Japan Asian Esophageal PB PCR-RFLP 56 561 561 145 3811 381 1 NA
Yokoyama 2001 Japan Asian Gastric PB PCR-RFLP 28 101 101 145 3811 381 1 NA
Takeshita 2000 Japan Asian Hepatocellular PB PCR-RFLP 3 36 63 8 43 74 Yes
Hori 1997 Japan Asian Esophageal HB PCR-RFLP 20 31 40 5 20 43 Yes

Abbreviations: APLP, amplified product length polymorphism; DHPLC, denaturing high-performance liquid chromatography; HB, hospital-based, NA, not applicable; PB, population-based; PCR-CTPP, PCR with the confronting-two-pair primer; PCR-RFLP, PCR-restriction fragment length polymorphism; UADT, upper aerodigestive tract.

1

The number of GA + AA.