Table 2. Meta-analysis of the association between the ADH1B Arg47His and cancer risk.

Variables	Sample size Case/control	Homozygous		Heterozygous		Recessive		Dominant		Allele comparison
		His/His vs. Arg/Arg		Arg/His vs. Arg/Arg		His/His vs. (Arg/His + Arg/Arg)		(Arg/His + His/His) vs. Arg/Arg		His vs. Arg
		OR (95% CI)	Phet	OR (95% CI)	Phet	OR (95% CI)	Phet	OR (95% CI)	Phet	OR (95% CI)	Phet
Total	31999/50964	0.62 (0.49–0.77)	<0.001	0.71 (0.60–0.84)	<0.001	0.83 (0.76–0.91)	<0.001	0.62 (0.53–0.72)	<0.001	0.82 (0.75–0.89)	<0.001
Ethnicity
Asian	17057/31885	0.60 (0.48–0.76)	<0.001	0.66 (0.53–0.81)	<0.001	0.82 (0.75–0.91)	<0.001	0.58 (0.47–0.72)	<0.001	0.80 (0.72–0.88)	<0.001
Caucasian	12970/16908	1.45 (1.05–2.02)	0.727	1.01 (0.90–1.13)	0.570	1.45 (1.05–2.00)	0.712	0.81 (0.64–1.03)	<0.001	1.06 (0.96–1.17)	0.569
Mixed	1972/2171	0.35 (0.13–0.93)	0.743	0.53 (0.37–0.75)	0.606	0.37 (0.14–0.98)	0.751	0.46 (0.36–0.60)	0.651	0.50 (0.36–0.68)	0.545
Cancer type
Colorectal	4821/7697	1.19 (0.82–1.72)	<0.001	0.99 (0.88–1.11)	0.857	1.19 (0.91–1.55)	<0.001	1.03 (0.88–1.21)	0.099	1.05 (0.90–1.23)	<0.001
Hepatocellular	1111/3820	0.84 (0.64–1.10)	0.541	1.16 (0.84–1.61)	0.328	0.81 (0.61–1.08)	0.041	0.98 (0.76–1.28)	0.452	0.88 (0.76–1.02)	0.270
Esophageal	9117/15930	0.39 (0.28–0.55)	<0.001	0.47 (0.34–0.64)	<0.001	0.72 (0.62–0.83)	<0.001	0.41 (0.31–0.54)	<0.001	0.67 (0.57–0.78)	<0.001
Gastric	1770/2930	1.02 (0.76–1.36)	0.637	1.03 (0.84–1.27)	0.356	1.02 (0.86–1.22)	0.973	0.77 (0.48–1.23)	<0.001	1.03 (0.92–1.16)	0.629
Head and neck	6646/7901	0.55 (0.31–0.97)	<0.001	0.77 (0.52–1.12)	<0.001	0.78 (0.66–0.93)	0.092	0.64 (0.47–0.87)	<0.001	0.80 (0.66–0.96)	<0.001
UADT	7613/9173	0.31 (0.23–0.42)	0.921	0.33 (0.21–0.53)	0.161	0.70 (0.57–0.86)	0.260	0.39 (0.26–0.58)	0.010	0.62 (0.54–0.71)	0.924
Pancreatic	395/1865	1.65 (0.62–4.38)	0.345	1.29 (0.76–2.20)	0.430	1.09 (0.78–1.52)	0.513	1.26 (0.75–2.13)	0.358	1.12 (0.86–1.45)	0.774
Control source
HB	10560/20932	0.53 (0.40–0.71)	<0.001	0.64 (0.51–0.81)	<0.001	0.79 (0.69–0.90)	<0.001	0.56 (0.44–0.72)	<0.001	0.77 (0.68–0.87)	<0.001
PB	21439/30032	0.75 (0.52–1.07)	<0.001	0.79 (0.61–1.02)	<0.001	0.89 (0.78–1.02)	<0.001	0.68 (0.54–0.85)	<0.001	0.87 (0.76–0.99)	<0.001
HWE
YES	20769/37678	0.60 (0.48–0.76)	<0.001	0.71 (0.60–0.84)	<0.001	0.81 (0.74–0.89)	<0.001	0.67 (0.56–0.81)	<0.001	0.81 (0.74–0.88)	<0.001
NO	1987/1892	0.75 (0.22–2.65)	<0.001	0.66 (0.23–1.90)	<0.001	1.08 (0.76–1.55)	0.006	0.72 (0.25–2.09)	<0.001	0.92 (0.59–1.45)	<0.001

Abbreviations: HB, hospital-based; PB, population-based; UADT, upper aerodigestive tract.

Values in bold indicate P<0.05.