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. 2019 Mar 26;11:62. doi: 10.3389/fnagi.2019.00062

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Copyright © 2019 Zeng, Long, Feng, Zhao, Luo, Wang, Wang, Yang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Valproic acid (VPA) improves cognitive ability in 3xTgAD mice. (A,B) Visible platform tests. The VPA-treated and control (saline-treated) Alzheimer’s disease (AD) mice exhibited a similar escape latency (A) and path length (B). (C,D) Hidden platform tests. The VPA-treated AD mice showed a shorter escape latency (C) and path length (D) on the fourth and fifth days. (E) Probe trial. The VPA-treated mice showed significantly more passing times in the target section where the platform was previously located than controls. *P < 0.05, **P < 0.01.