Table 1.
Baseline characteristics of control and CAD patients, subdivided into statin pretreatment or naïve before PCI procedures.
| Control (n = 50) | CAD (n = 138) | Statin naive (n = 58) | Statin pretreated (n = 80) | |
|---|---|---|---|---|
| Age, years | 62 ± 10 | 61 ± 13 | 61 ± 15 | 61 ± 15 |
| Male, sex (%) | 35 (70) | 94 (68.1) | 40 (68.9) | 54 (67.5) |
| Smoking (%) | 20 (40) | 67 (48.6)* | 27 (46.5) | 40 (50.0) |
| Diabetes mellitus (%) | 5 (10) | 27 (19.5)** | 10 (17.2) | 14 (17.5) |
| Hypertension (%) | 12 (24) | 76 (55.0)** | 30 (52) | 43 (53.7) |
| Total cholesterol, mg/dl | 196 ± 40 | 206 ± 34* | 208 ± 25 | 205 ± 30 |
| HDL-cholesterol, mg/dl | 52 ± 14 | 46 ± 20* | 47 ± 26 | 46 ± 14 |
| LDL-cholesterol, mg/dl | 123 ± 38 | 131 ± 40** | 132 ± 33 | 131 ± 47 |
| Triglycerides, mg/dl | 133 ± 42 | 135 ± 43 | 136 ± 55 | 135 ± 53 |
| BM1, kg/m2 | 22.1 ± 4.2 | 23.0 ± 5.1 | 23.1 ± 4.3 | 23.0 ± 3.1 |
| Number of risk factors | 1.3 ± 1.5 | 2.3 ± 1.7** | 2.3 ± 1.9 | 2.5 ± 2.3 |
| CRP, mg/dl | 0.46 (0.18–2.56) | 3.25** (1.28–5.88) | 3.23 (1.28–4.98) | 3.26 (1.33–5.88) |
| ROCK activity (pMBS/tMBS ratio) | 0.21 (0.12–0.62) | 0.40** (0.27–1.02) | 0.42 (0.27–0.89) | 0.40 (0.28–1.02) |
| Previous MI (%) | - | 21 (15.2) | 8 (13.7) | 13 (16.2) |
Values are expressed as mean ± SD or number, or median with inter-quartile range. BMI = body mass index; CRP = C – reactive protein; MI = myocardial infarction; PCI = percutaneous coronary intervention; LDL = low-density lipoprotein; HDL = high-density lipoprotein; NA = not analyzed; ROCK = Rho kinase.
*
P < 0.05,
**
P < 0.01 compared between normal control and CAD groups; there was no difference between statin naïve and statin pretreated subgroups.