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. 2019 Mar 25;10:119. doi: 10.3389/fphar.2019.00119

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Copyright © 2019 Cao, Shi, Sun, Wu, Xia, Wang, Wu, Li, Chen, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of MgIG and MTX on body weight and liver weight/body weight ratio. (A) Experimental protocols for MTX-induced hepatotoxicity in rats pretreated with MgIG and GSH; (B) body weight; (C) liver weight/body weight ratio [Liver/wt ratio (%)]; (D) effects of treatment with MgIG and GSH on histopathological lesions in liver tissues following MTX-induced hepatotoxicity. Microscopic views from the pericentral zone of rat liver stained with HE are shown; magnifications: ×400. Values of body weight and liver weight are shown as mean ±SD, n = 6. Significance: Compared with control: ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001; compared with MTX group: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001; compared with GSH group: $P < 0.05. The arrow means congestion of RBCs, infiltration of inflammatory cells and pyknosis in liver.