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. 2019 Mar 25;10:119. doi: 10.3389/fphar.2019.00119

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Copyright © 2019 Cao, Shi, Sun, Wu, Xia, Wang, Wu, Li, Chen, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of MgIG on MTX induced intestinal damage (A) Immunofluorescence analysis of ZO-1 (green); (B) intestinal sections were stained with HE; (C) chromatograms of lactose and mannitol; (D) lactulose and mannitol excretion in the urine of rats. The results are shown as means ±SD of six rats per group. Compared with control group: ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001; compared with MTX group: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001.