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. 2019 Mar 25;10:119. doi: 10.3389/fphar.2019.00119

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Copyright © 2019 Cao, Shi, Sun, Wu, Xia, Wang, Wu, Li, Chen, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepatoprotective effect of MgIG on MTX-induced intestinal toxicity by regulating COX-2 and colocalization of ZO-1 and Cx43: (A) Effect of MgIG on MTX induced damage in intestinal tissue and immunohistochemistry of COX-2 in rat intestinal sections (Magnifications: × 200); (B) quantification of percentage of COX-2 positive cells (pos cells); (C) immunofluorescence analysis of Cx43 (red) and ZO-1 (green). The results are shown as means ±SD of three rats per group. Compared with control group: ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001; compared with MTX group: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001. The arrow means colocalization of ZO-1 and connexin 43 in liver.