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. 2019 Feb 13;41:62–72. doi: 10.1016/j.ebiom.2019.02.019

Fig. 2.

Fig. 2

OA-NO2 improves body composition and increases respiratory quotient in NASH-diet induced steatohepatitis. (a) Gross appearance of the peritoneal cavity at the experimental end-point (24 weeks) depicting apparent reduction of liver steatosis upon treatment with OA-NO2. One week before end-point analysis, NMR-based body composition analysis was conducted (n = 8) revealing a significant reduction of % body fat (b) and subsequent increase in % lean body mass (c), upon OA-NO2 treatment. No alteration in body composition was observed in mice treated with equimolar amounts of non-nitrated OA. Quantitative data is plotted as box and whiskers from minimum to maximum values showing all points. (d) OA-NO2 increased the respiratory exchange ratio (RER) calculated as the ratio of CO2 generation vs. oxygen consumption (VCO2/VO2) assessed by CLAMS. Data are shown over a 24 h dark/light period cycle (n = 8). (e) Quantitative analysis of RER in each experimental group shown as box and whiskers from minimum to maximum values. Data is shown as mean ± SEM. *p < .05, **p < .01, ***p < .001 vs CD PEG; #p < .05, ##p < .01, ###p < .001 vs. NASH PEG ^p < .05 vs. NASH OA.