Fig. 1.

(a) genetics of mouse lines used, (b) ChR2-dtTomato (ChR2, red) is expressed in ChI (Chat, green), arrows point at three striatal neurons, scale bar is 20 μm. (c) Localization of the optical fiber cannula in the dorsolateral striatum (Str). (d-g) Distance moved or (h) velocity normalized to respective baseline (mean of min 1–3) for 6 months old wildtype/ChR2 (WT, open circles) and DYT1 KI/ChR2 (DYT, closed circles) at 10 Hz and different pulse durations (5 ms and 25 ms, WT n = 11, DYT n = 8; 10 ms, WT n = 7, DYT n = 6; 1 s, WT n = 8, DYT n = 6), *p < 0.05 compared to off periods (Holm-Sidak), means ± SEM, (i) Immobility frequency at 25 ms, median, 10th, 25th, 75th and 90th percentiles, *p < 0.05 (Holm-Sidak), (j) distance moved during 60 min stimulation at 25 ms 10 Hz, WT n = 4, DYT n = 4, *p < 0.05 compared to wildtype (Holm-Sidak), (k) time to remove the adhesive sticker, median, 10^th, 25^th, 75^th and 90^th percentiles, WT n = 8, DYT n = 6, ^^,*^,**p < 0.1, 0.05, 0.01 versus corresponding wildtype (rank sum test). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)