Fig. 3.

(a) Substance P (SP) immunoreactivity (green) in a coronal section of the striatum (aca, anterior part of anterior commissure; VP, ventral pallidum; CPu, striatum). (b) Representative microscopic images of SP (green) and c-Fos (red) colabelling in the striatum, white outline depicts one striosome, scale bar is 50 μm. (c) Representative confocal slice with single SP and c-Fos positive neurons in the matrix, scale bar is 25 μm. (d) Bar graph with quantification of mean c-Fos immunoreactivity in striosome and matrix (naive, WT n = 4, DYT n = 6; 10 min light on +15 min delay before sacrifice, WT n = 6, DYT n = 5), mean + SEM. (e) Bar graph with quantification of c-Fos immunoreactivity in SP positive neurons in the matrix, mean + SEM. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)