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. 2019 Apr;27(4):712–722. doi: 10.1016/j.joca.2018.12.017

Fig. 5.

Fig. 5

Shows mRNA expression of glia cells and cytokines in the lumbar dorsal horn of EP and LP MIA animals (EP n = 4, EPS n = 4, LP n = 4, LPS n = 4). A) mRNA expression of Iba1 and glial fibrillary acid protein (GFAP) normalized to sham. B) mRNA expression of pro-inflammatory cytokines normalized to sham. C) There is a weak rise in Iba1 mRNA expression in LP MIA animals. D) GFAP mRNA levels remain similar between MIA and sham groups. E) There is a significant increase in IL-1β mRNA expression in LP MIA animals. F) IL-6 mRNA levels remain similar between MIA and sham groups. G) TNFα mRNA levels remain similar between MIA and sham groups (A–B: for mRNA expression normalized to sham controls a Kruskall–Wallis test was used, C–G: for mRNA expression expressed as 2-ΔCT values an independent samples t-test was used. *P < 0.05).