Table 5.
Correlations between the comprehension, coding, and cancellation scores on the WISC-IV and the FA, MD, AD, and RD of white matter tracts
| Comprehension |
Coding |
Cancellation |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ASD (N=17) |
TD (N=18) |
ASD (N=17) |
TD (N=18) |
ASD (N=17) |
TD (N=18) |
||||||||
| r value | p value | r value | p value | r value | p value | r value | p value | r value | p value | r value | p value | ||
| SLF left | FA | -0.17 | 0.526 | 0.47 | 0.047* | 0.25 | 0.334 | 0.11 | 0.670 | 0.08 | 0.747 | -0.13 | 0.616 |
| MD | 0.28 | 0.273 | -0.62 | 0.006* | 0.15 | 0.555 | -0.31 | 0.214 | 0.25 | 0.331 | -0.08 | 0.763 | |
| AD | 0.14 | 0.604 | -0.36 | 0.138 | 0.25 | 0.328 | -0.29 | 0.249 | 0.26 | 0.316 | -0.20 | 0.422 | |
| RD | 0.30 | 0.246 | -0.62 | 0.006* | 0.00 | 0.994 | -0.23 | 0.355 | 0.14 | 0.589 | 0.04 | 0.879 | |
| SLF right | FA | -0.02 | 0.933 | 0.53 | 0.023* | 0.06 | 0.819 | 0.07 | 0.796 | 0.10 | 0.696 | 0.00 | 0.991 |
| MD | 0.28 | 0.270 | -0.52 | 0.026* | -0.07 | 0.794 | -0.17 | 0.504 | 0.06 | 0.813 | 0.07 | 0.787 | |
| AD | 0.25 | 0.331 | -0.20 | 0.424 | -0.08 | 0.751 | -0.19 | 0.460 | 0.08 | 0.754 | 0.00 | 0.991 | |
| RD | 0.23 | 0.368 | -0.59 | 0.009* | -0.04 | 0.887 | -0.10 | 0.701 | 0.03 | 0.914 | 0.10 | 0.694 | |
| ILF left | FA | -0.31 | 0.220 | 0.31 | 0.213 | -0.05 | 0.841 | 0.23 | 0.360 | -0.29 | 0.253 | 0.15 | 0.559 |
| MD | 0.14 | 0.587 | -0.45 | 0.058 | -0.43 | 0.084 | 0.02 | 0.950 | -0.39 | 0.117 | 0.13 | 0.628 | |
| AD | -0.04 | 0.871 | -0.26 | 0.294 | -0.37 | 0.142 | 0.28 | 0.253 | -0.51 | 0.035* | 0.37 | 0.132 | |
| RD | 0.25 | 0.324 | -0.43 | 0.072 | -0.32 | 0.211 | -0.12 | 0.632 | -0.13 | 0.610 | -0.03 | 0.903 | |
| ILF right | FA | -0.08 | 0.751 | 0.56 | 0.015* | 0.06 | 0.822 | 0.24 | 0.338 | -0.25 | 0.341 | 0.04 | 0.883 |
| MD | 0.37 | 0.143 | -0.47 | 0.049* | -0.17 | 0.502 | 0.00 | 0.996 | 0.13 | 0.612 | 0.10 | 0.682 | |
| AD | 0.29 | 0.270 | 0.00 | 0.996 | -0.06 | 0.830 | 0.33 | 0.186 | -0.12 | 0.658 | 0.26 | 0.303 | |
| RD | 0.24 | 0.349 | -0.55 | 0.017* | -0.17 | 0.526 | -0.14 | 0.580 | 0.23 | 0.379 | 0.01 | 0.965 | |
| IFO left | FA | -0.06 | 0.811 | 0.55 | 0.018* | -0.05 | 0.856 | 0.21 | 0.393 | 0.00 | 0.987 | 0.31 | 0.217 |
| MD | 0.25 | 0.330 | -0.44 | 0.065 | -0.35 | 0.164 | -0.01 | 0.960 | 0.29 | 0.256 | 0.25 | 0.327 | |
| AD | 0.24 | 0.360 | -0.01 | 0.969 | -0.35 | 0.174 | 0.13 | 0.615 | -0.23 | 0.380 | 0.52 | 0.028* | |
| RD | 0.17 | 0.503 | -0.56 | 0.015* | -0.24 | 0.362 | -0.10 | 0.683 | -0.24 | 0.346 | -0.04 | 0.878 | |
| IFO right | FA | -0.37 | 0.141 | 0.71 | 0.0009** | -0.27 | 0.290 | 0.53 | 0.023* | -0.35 | 0.170 | 0.44 | 0.071 |
| MD | 0.00 | 0.995 | -0.51 | 0.032* | -0.44 | 0.080 | 0.11 | 0.678 | -0.19 | 0.474 | 0.16 | 0.524 | |
| AD | -0.15 | 0.560 | -0.01 | 0.969 | -0.51 | 0.037* | 0.62 | 0.006* | -0.33 | 0.189 | 0.63 | 0.005* | |
| RD | 0.17 | 0.530 | -0.66 | 0.003** | -0.27 | 0.290 | -0.20 | 0.426 | 0.01 | 0.976 | -0.13 | 0.601 | |
| UNC left | FA | -0.01 | 0.978 | 0.43 | 0.072 | -0.12 | 0.641 | 0.05 | 0.838 | -0.14 | 0.587 | 0.14 | 0.579 |
| MD | 0.32 | 0.215 | -0.20 | 0.423 | -0.35 | 0.166 | 0.21 | 0.399 | -0.10 | 0.693 | 0.17 | 0.493 | |
| AD | 0.35 | 0.172 | 0.18 | 0.483 | -0.52 | 0.032* | 0.36 | 0.139 | -0.24 | 0.343 | 0.43 | 0.073 | |
| RD | 0.22 | 0.386 | -0.31 | 0.218 | -0.16 | 0.528 | 0.12 | 0.650 | 0.01 | 0.971 | 0.04 | 0.866 | |
| UNC right | FA | -0.02 | 0.950 | 0.41 | 0.088 | 0.08 | 0.774 | 0.07 | 0.779 | -0.08 | 0.768 | -0.13 | 0.599 |
| MD | 0.14 | 0.598 | -0.42 | 0.086 | -0.38 | 0.134 | 0.06 | 0.800 | 0.84 | 0.748 | 0.15 | 0.561 | |
| AD | 0.14 | 0.592 | -0.23 | 0.348 | -0.40 | 0.113 | 0.15 | 0.545 | 0.03 | 0.909 | 0.11 | 0.665 | |
| RD | 0.11 | 0.671 | -0.43 | 0.073 | -0.30 | 0.246 | 0.02 | 0.942 | 0.10 | 0.840 | 0.14 | 0.575 | |
| ATR left | FA | -0.51 | 0.037* | 0.67 | 0.002** | -0.48 | 0.053 | 0.53 | 0.024* | -0.13 | 0.627 | 0.54 | 0.021* |
| MD | 0.41 | 0.106 | -0.75 | 0.0003** | -0.11 | 0.670 | -0.39 | 0.107 | -0.19 | 0.470 | -0.14 | 0.582 | |
| AD | 0.07 | 0.781 | -0.17 | 0.507 | -0.41 | 0.098 | 0.09 | 0.720 | -0.23 | 0.383 | 0.42 | 0.086 | |
| RD | 0.52 | 0.033* | -0.80 | 0.0001** | 0.13 | 0.630 | -0.50 | 0.033* | -0.11 | 0.676 | -0.36 | 0.140 | |
| ATR right | FA | -0.34 | 0.181 | 0.40 | 0.099 | 0.24 | 0.351 | 0.49 | 0.040* | -0.11 | 0.681 | 0.61 | 0.008* |
| MD | 0.52 | 0.034* | -0.56 | 0.015* | -0.07 | 0.797 | -0.29 | 0.237 | 0.14 | 0.588 | -0.02 | 0.926 | |
| AD | 0.26 | 0.314 | -0.40 | 0.101 | 0.11 | 0.671 | -0.08 | 0.752 | 0.05 | 0.836 | 0.40 | 0.101 | |
| RD | 0.52 | 0.033* | -0.56 | 0.015* | -0.17 | 0.514 | -0.38 | 0.125 | 0.15 | 0.555 | 0.29 | 0.243 | |
| F minor | FA | -0.34 | 0.186 | 0.50 | 0.034* | 0.15 | 0.561 | 0.21 | 0.410 | 0.05 | 0.840 | 0.22 | 0.375 |
| MD | 0.68 | 0.003** | -0.43 | 0.079 | -0.15 | 0.574 | 0.01 | 0.972 | 0.15 | 0.555 | 0.17 | 0.495 | |
| AD | 0.55 | 0.022* | 0.07 | 0.772 | -0.01 | 0.985 | 0.26 | 0.301 | 0.28 | 0.270 | 0.52 | 0.028* | |
| RD | 0.56 | 0.019* | -0.53 | 0.024* | -0.18 | 0.496 | -0.13 | 0.617 | 0.05 | 0.844 | -0.08 | 0.767 | |
| F major | FA | 0.31 | 0.221 | 0.52 | 0.027* | 0.05 | 0.859 | 0.28 | 0.268 | 0.05 | 0.852 | 0.17 | 0.499 |
| MD | 0.17 | 0.527 | -0.35 | 0.154 | -0.03 | 0.917 | -0.09 | 0.716 | 0.19 | 0.469 | 0.11 | 0.675 | |
| AD | 0.44 | 0.075 | -0.10 | 0.703 | 0.03 | 0.895 | 0.01 | 0.982 | 0.30 | 0.235 | 0.19 | 0.460 | |
| RD | -0.04 | 0.886 | -0.48 | 0.045* | -0.07 | 0.801 | -0.16 | 0.539 | 0.09 | 0.730 | 0.00 | 0.998 | |
Units of axial diffusivity and radial diffusivity are 10-3 mm2/s for the mean and standard deviation.
*
p<0.05 (significance level),
**
p<0.004 (significance level after Bonferroni correction).
WISC-IV: Wechsler Intelligence Scale for Children-Fourth Edition, FA: fractional anisotropy, MD: mean diffusivity, AD: axial diffusivity, RD: radial diffusivity, ASD: autism spectrum disorder, TD: typically developing, SLF: superior longitudinal fasciculus, ILF: inferior longitudinal fasciculus, IFO: inferior fronto-occipital fasciculus, UNC: uncinate fasciculus, ATR: anterior thalamic radiation, F minor: forceps minor, F major: forceps major