Table 1.
Parameter | Control vs. AlCl3 | AlCl3 vs. AlCl3+AST | AlCl3 vs. AlCl3+LC | AlCl3+LC vs. AlCl3+AST |
---|---|---|---|---|
Radial arm maze test | ||||
Working memory correct | ∗ | ∗ | ∗ | – |
Working memory incorrect | ∗∗∗ | ∗ | – | – |
% Entry to the target arm | – | – | – | – |
% Time spent in the target arm | – | – | ∗ | – |
Oxidative stress | ||||
MDA | ||||
Prefrontal cortex | ∗∗∗ | ∗∗∗ | – | ↓∗ |
Striatum | ∗∗∗ | ∗∗∗ | ∗ | ↓ |
Parietal Cortex | ∗∗∗ | ∗∗∗ | ∗∗∗ | ↓ |
Hypothalamus | ∗∗∗ | ∗∗∗ | ∗∗∗ | ↓ |
Hippocampus | ∗∗∗ | ∗∗∗ | ∗∗ | ↓ |
Cerebellum | ∗∗∗ | ∗∗∗ | – | ↓ |
AOPP | ||||
Prefrontal cortex | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Striatum | ∗∗∗ | ∗∗∗ | ∗∗∗ | ↓ |
Parietal Cortex | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Hypothalamus | ∗∗ | ∗∗ | ∗∗∗ | ∗ |
Hippocampus | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Cerebellum | – | ∗∗∗ | ∗∗∗ | – |
GSH | ||||
Prefrontal cortex | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Striatum | ∗∗∗ | ∗∗ | ∗∗∗ | ↑ |
Parietal Cortex | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Hypothalamus | ∗∗∗ | ∗∗∗ | ∗∗∗ | ↓ |
Hippocampus | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
Cerebellum | ∗∗∗ | ∗∗∗ | ∗∗∗ | – |
NO | ||||
Prefrontal cortex | ∗∗∗ | ∗ | ∗∗∗ | ↓ |
Striatum | ∗∗∗ | – | ∗∗∗ | ↓∗ |
Parietal Cortex | ∗∗∗ | – | ∗∗∗ | ↓∗ |
Hypothalamus | ∗∗∗ | – | ∗∗∗ | ↓∗ |
Hippocampus | ∗∗∗ | – | ∗∗∗ | ↓∗ |
Cerebellum | ∗∗∗ | – | ∗∗∗ | ↓∗ |
SOD | ||||
Prefrontal cortex | – | – | – | – |
Striatum | – | – | – | – |
Parietal Cortex | ∗ | ∗∗ | ∗ | – |
Hypothalamus | – | – | – | – |
Hippocampus | – | – | – | – |
Cerebellum | – | – | – | – |
↓ Decrease; ↑ Increase; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.