Table 3.
Hematological parameters in rats administered blueberry leaf powder for 13 weeks.
| Weeks | Dose groups (mg/kg body weight/day) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Males |
Females |
||||||||
| Control (n = 9)1 |
500 (n = 10) |
1000 (n = 10) |
2500 (n = 10) |
Control (n = 10) |
500 (n = 9)1 |
1000 (n = 10) |
2500 (n = 10) |
||
| WBC (103/μL) | 7.19 ± 0.68 | 8.83 ± 1.43* | 7.62 ± 1.87 | 7.31 ± 0.96 | 5.71 ± 1.55 | 6.51 ± 0.73 | 6.64 ± 2.17 | 6.30 ± 1.21 | |
| RBC (106/μL) | 8.90 ± 0.30 | 9.14 ± 0.33 | 8.88 ± 0.28 | 8.99 ± 0.30 | 8.48 ± 0.38 | 8.49 ± 0.29 | 8.54 ± 0.30 | 8.26 ± 0.42 | |
| HGB (g/dL) | 14.4 ± 0.6 | 14.9 ± 0.5 | 14.4 ± 0.4 | 14.5 ± 1.0 | 14.9 ± 0.3 | 15.2 ± 0.4 | 15.1 ± 0.5 | 14.6 ± 1.0 | |
| HCT (%) | 42.3 ± 1.4 | 42.1 ± 1.5 | 41.5 ± 1.4 | 42.8 ± 1.6 | 46.2 ± 1.5 | 46.6 ± 1.7 | 46.7 ± 1.9 | 44.6 ± 2.9 | |
| MCV (fL) | 47.4 ± 1.4 | 46.1 ± 1.4 | 46.8 ± 1.0 | 47.8 ± 0.9 | 54.7 ± 2.6 | 55.2 ± 1.9 | 54.7 ± 1.9 | 53.9 ± 2.0 | |
| MCH (pg) | 16.2 ± 0.5 | 16.3 ± 0.9 | 16.2 ± 0.2 | 16.1 ± 1.1 | 17.6 ± 0.4 | 17.9 ± 0.4 | 17.7 ± 0.3 | 17.6 ± 0.5 | |
| MCHC (g/dL) | 0.34 ± 0.01 | 0.35 ± 0.02 | 0.35 ± 0.01 | 0.34 ± 0.03 | 0.32 ± 0.01 | 0.33 ± 0.01 | 0.32 ± 0.01 | 0.33 ± 0.01 | |
| PLT (104/μL) | 8.71 ± 1.85 | 8.97 ± 1.77 | 8.82 ± 1.68 | 8.18 ± 1.55 | 7.82 ± 1.78 | 8.02 ± 1.14 | 7.67 ± 1.11 | 7.97 ± 1.93 | |
| Leukocyte fractionation (%) | |||||||||
| Neutrophil | 14.5 ± 2.5 | 18.2 ± 4.7 | 21.8 ± 5.9* | 19.1 ± 8.3 | 17.6 ± 3.9 | 19.1 ± 7.7 | 25.4 ± 9.6 | 25.6 ± 7.3 | |
| Lymphocyte | 80.2 ± 3.2 | 74.8 ± 6.1 | 71.8 ± 6.5* | 74.7 ± 10.1 | 76.6 ± 5.7 | 75.0 ± 9.4 | 68.1 ± 10.4 | 68.8 ± 8.0 | |
| Monocyte | 2.93 ± 0.57 | 2.90 ± 0.78 | 2.99 ± 0.39 | 3.75 ± 1.32 | 2.87 ± 0.81 | 2.34 ± 0.41 | 2.53 ± 0.42 | 2.78 ± 0.77 | |
| Eosinophil | 2.34 ± 1.10 | 4.01 ± 1.48* | 3.45 ± 1.23 | 2.52 ± 1.53 | 2.78 ± 1.35 | 3.52 ± 1.82 | 3.84 ± 1.99 | 2.80 ± 1.33 | |
| Basophil | 0.04 ± 0.05 | 0.03 ± 0.05 | 0.03 ± 0.07 | 0.01 ± 0.03 | 0.16 ± 0.33 | 0.06 ± 0.08 | 0.09 ± 0.19 | 0.06 ± 0.08 | |
All values represent the mean ± S.D. HCT, hematocrit; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; PLT, platelet; RBC, red blood cell; WBC, white blood cell.1One data was missing, because one blood sample was coagulated before analysis. No significant differences were found between control and treated rats (P < 0.05, Dunnett’s test).