Table 6.
Dose groups (mg/kg body weight/day) |
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---|---|---|---|---|---|---|---|---|
Males (n = 10) |
Females (n = 10) |
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Control | 500 | 1000 | 2500 | Control | 500 | 1000 | 2500 | |
Absolute organ weights (g) | ||||||||
Body weights | 481 ± 50 | 453 ± 41 | 462 ± 48 | 442 ± 38 | 266 ± 28 | 265 ± 24 | 259 ± 20 | 265 ± 22 |
Liver | 12.1 ± 1.6 | 11.3 ± 1.1 | 11.9 ± 1.9 | 11.0 ± 1.2 | 6.8 ± 0.4 | 6.4 ± 0.7 | 6.6 ± 0.6 | 6.9 ± 0.5 |
Kidney | 2.69 ± 0.28 | 2.65 ± 0.42 | 2.66 ± 0.24 | 2.58 ± 0.22 | 1.62 ± 0.15 | 1.55 ± 0.14 | 1.55 ± 0.12 | 1.62 ± 0.12 |
Adrenal | 0.057 ± 0.015 | 0.055 ± 0.011 | 0.062 ± 0.013 | 0.056 ± 0.010 | 0.068 ± 0.010 | 0.069 ± 0.009 | 0.068 ± 0.013 | 0.072 ± 0.010 |
Spleen | 0.81 ± 0.08 | 0.74 ± 0.11 | 0.79 ± 0.10 | 0.78 ± 0.08 | 0.51 ± 0.07 | 0.51 ± 0.06 | 0.54 ± 0.06 | 0.54 ± 0.07 |
Heart | 1.28 ± 0.12 | 1.22 ± 0.12 | 1.25 ± 0.11 | 1.21 ± 0.08 | 0.78 ± 0.07 | 0.72 ± 0.06 | 0.75 ± 0.04 | 0.75 ± 0.04 |
Lung | 1.46 ± 0.13 | 1.51 ± 0.17 | 1.52 ± 0.11 | 1.40 ± 0.09 | 1.03 ± 0.05 | 1.04 ± 0.06 | 1.06 ± 0.07 | 1.06 ± 0.08 |
Visceral fat1 | 7.9 ± 2.4 | 7.5 ± 2.5 | 7.1 ± 2.4 | 6.1 ± 2.1 | 5.19 ± 2.40 | 6.10 ± 5.14 | 6.10 ± 4.84 | 4.18 ± 1.98 |
Thymus | 0.440 ± 0.076 | 0.366 ± 0.090 | 0.389 ± 0.093 | 0.343 ± 0.05 | 0.324 ± 0.030 | 0.300 ± 0.048 | 0.285 ± 0.047 | 0.270 ± 0.051 |
Thyroid | 0.015 ± 0.002 | 0.014 ± 0.004 | 0.014 ± 0.002 | 0.014 ± 0.003 | 0.010 ± 0.003 | 0.011 ± 0.002 | 0.012 ± 0.003 | 0.012 ± 0.003 |
Relative organ weight (g/100 g body weight) | ||||||||
Liver | 2.51 ± 0.18 | 2.48 ± 0.11 | 2.56 ± 0.21 | 2.49 ± 0.13 | 2.58 ± 0.15 | 2.42 ± 0.16 | 2.54 ± 0.16 | 2.60 ± 0.17 |
Kidney | 0.561 ± 0.048 | 0.585 ± 0.076 | 0.578 ± 0.025 | 0.583 ± 0.032 | 0.612 ± 0.049 | 0.587 ± 0.042 | 0.599 ± 0.029 | 0.613 ± 0.058 |
Adrenal | 0.012 ± 0.003 | 0.012 ± 0.003 | 0.014 ± 0.003 | 0.013 ± 0.002 | 0.025 ± 0.003 | 0.026 ± 0.005 | 0.026 ± 0.005 | 0.027 ± 0.004 |
Spleen | 0.169 ± 0.015 | 0.162 ± 0.013 | 0.172 ± 0.021 | 0.177 ± 0.012 | 0.191 ± 0.021 | 0.194 ± 0.030 | 0.210 ± 0.019 | 0.203 ± 0.027 |
Heart | 0.267 ± 0.015 | 0.269 ± 0.015 | 0.272 ± 0.017 | 0.275 ± 0.020 | 0.295 ± 0.024 | 0.274 ± 0.016 | 0.290 ± 0.013 | 0.285 ± 0.023 |
Lung | 0.305 ± 0.019 | 0.335 ± 0.031 | 0.331 ± 0.029 | 0.318 ± 0.025 | 0.392 ± 0.035 | 0.394 ± 0.037 | 0.411 ± 0.049 | 0.404 ± 0.038 |
Visceral fat1 | 1.65 ± 0.49 | 1.64 ± 0.48 | 1.52 ± 0.46 | 1.37 ± 0.39 | 1.90 ± 0.70 | 2.24 ± 1.75 | 2.30 ± 1.72 | 1.55 ± 0.61 |
Thymus | 0.092 ± 0.017 | 0.080 ± 0.016 | 0.084 ± 0.17 | 0.077 ± 0.008* | 0.122 ± 0.011 | 0.114 ± 0.019 | 0.110 ± 0.015 | 0.103 ± 0.022* |
Thyroid | 0.0031 ± 0.0005 | 0.0032 ± 0.0010 | 0.0030 ± 0.0004 | 0.0032 ± 0.0007 | 0.0039 ± 0.0011 | 0.0040 ± 0.0007 | 0.0045 ± 0.0015 | 0.0047 ± 0.0012 |
All values represent the mean ± S.D. 1Mesenteric fat. No significant differences were found between control and treated rats (P < 0.05, Dunnett’s test).