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. 2019 Mar 7;41:299–309. doi: 10.1016/j.ebiom.2019.02.059

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — hnRNPM expression is associated with colon cancer (CRC) development and prognosis. (a) Immunoblots (upper panel) and quantified results (lower panel panel) of levels of hnRNPM in normal colon cells (CRL1790) and 8 CRC cell lines (n = 3). α–tubulin served as a loading control. ^⁎⁎P < .01; ^⁎⁎⁎P < .001 (Student's t-test). (b) Representative images of immunochemical (IHC) staining of hnRNPM in paired CRC tumor and noncancerous tissues with indicated Duke's stage A to D (number indicates patient ID used for the IHC). Lower panel under each tissue sample indicates amplified images from the box marked region. (c) A Box and Whisker plot shows the quantified IHC intensity of hnRNPM in paired noncancerous (Nor) and cancer (Ca) tissues. The number (N) of involved cases for each indicated stage is shown. ^⁎⁎P < .01; ^⁎⁎⁎P < .001 (Student's t-test). The ends of the box are the upper and lower quartiles while the Whisker shows standard deviation. (d) Kaplan-Meier survival curve shows the overall survival probability between CRCs with high (top 30%, n = 43) and low (bottom 30%, n = 35) hnRNPM expressions. (e) Representative images (case number #28) show the IHC staining of hnRNPM, FGF9 and HIF-1α in paired noncancerous (Normal) and cancer tissues. (f) The correlations between hnRNPM- and FGF9-positive cells (left), and between hnRNPM- and HIF1-α-positive cells (right) in paired non-cancerous and CRC cases (n = 40) were plotted (Spearman's correlation test).