Fig. 4.

Expression of hnRNPM is positively correlated with cancer progression in the mouse model of AOM-induced tumorigenesis. (a), Schematic representation of the experimental protocol of AOM/DSS murine model to induce CRC. The AOM was injected at Day 1 (arrow), followed by giving DSS at weeks 1, 4, and 7 (Bold line). The arrowhead indicates time points when the tissues were collected. (b) IHC images shows the IHC staining of hnRNPM in the colon sections of AOM/DSS-treated mice. Saline-injected and age-matched mice were used as control for AOM/DSS treatment; normal rabbit IgG was used as negative control for IHC. (c), The plot shows the comparison of hnRNPM-positive cells from IHC staining in indicated AOM/DSS-treated mice groups (n = 3–6). ^⁎⁎⁎P < .001 (ANOVA followed by Tukey's multiple test).