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. 2019 Mar 26;10:272. doi: 10.3389/fphar.2019.00272

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Copyright © 2019 Lai, Guo, Chen, Tang, Shuai, Yong, Wang, Xiao, Zhou, Xie, Yang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of Histone H3, DNMT3A and DNMT3B protein in the brain of alcohol extracts from G. lucidum treated APP/PS1 mice detected using IHC. Control and model group that received oral distilled water. Dosage of 50 mg/[kg⋅d] is AEGL, and 100 mg/[kg⋅d] is AEGH, and the extracts were dissolved in distilled water and were given by intragastric administration once daily for 24 weeks, alcohol (AEG) extracts from G. lucidum by gavage. (A) Brain tissue IHC detection; (B–E) Average optical density of brain tissue IHC detection. ^∗p < 0.05 and ^∗∗p < 0.01.