Table IV.
Comparison of clinical features and risk factor exposure in HPV-related and unrelated OPSCC patients.
| Group | Sex | Age (years) | Stagea | Surgery | Smokea | Alcohola | |||
|---|---|---|---|---|---|---|---|---|---|
| M/F | Mean ± SD | 0-1 | T/N | 3 | 4 | T/N | Y/Nb | Y/N | |
| 1992-2010 | 45/8 | 58.1 ± 10.7 | 4 | 13 | 15 | 21 | 20/18 | 28/6 | 23/12 |
| HPV + | 10/5 | 56.7 ± 10.7 | 2 | 3 | 4 | 6 | 8/6 | 4/4 | 5/3 |
| HPV - | 35/3 | 58.6 ± 10.8 | 2 | 10 | 11 | 15 | 12/12 | 24/2 | 18/9 |
| p | 0.03 | Ns | Ns | Ns | 0.01 | Ns | |||
| 2010-2015 | 56/15 | 63.8 ± 10 | 6 | 6 | 16 | 43 | 22/25 | 41/21 | 29/25 |
| HPV + | 27/5 | 63.7 ± 10 | 1 | 3 | 8 | 20 | 11/14 | 15/13 | 8/17 |
| HPV - | 29/10 | 63.9 ± 10 | 5 | 3 | 8 | 23 | 10/11 | 26/8 | 21/8 |
| p | Ns | Ns | Ns | Ns | 0.06 | 0.006 | |||
| Total | 101/23 | 61.4 ± 10.8 | 10 | 19 | 31 | 63 | 44/43 | 69/27 | 52/37 |
| HPV + | 37/10 | 61.5 ± 11.1 | 3 | 6 | 12 | 25 | 19/20 | 19/17 | 13/20 |
| HPV - | 64/13 | 61.3 ± 10.6 | 7 | 13 | 19 | 38 | 22/23 | 50/10 | 39/17 |
| p | Ns | Ns | Ns | Ns | 0.002 | 0.007 | |||
a: data not available for the complete case series
b: never smoker or former smoker quitting more than 5 years before cancer diagnosis
M: male; F: female; SD: standard deviation; Y: yes; N: no; Ns: not significant.