Table V.
Comparison of outcomes in HPV-related and unrelated OPSCC patients.
| Group | CRa | LRRa | DRa | DFSa | DSDa |
|---|---|---|---|---|---|
| Y/N | Y/N | Y/N | Median (IQR) | Y/N | |
| 1992-2010 | 40/9 | 19/21 | 5/35 | 34 (12-65) | 25/24 |
| HPV + | 14/1 | 2/12 | 0/14 | 65.5 (60-90) | 2/13 |
| HPV - | 26/8 | 17/9 | 5/21 | 24 (8-60) | 23/11 |
| p | Ns | 0.003 | Ns | 0.001 | 0.001 |
| OR (95% CI) | 4.3 (0.4-101) | 0.08 (0.01-0.5) | 0 (0-2.1) | 0.07 (0.009-0.4) | |
| 2010-2015 | 54/17 | 9/45 | 2/52 | 17 (8-36) | 17/53 |
| HPV + | 30/2 | 2/28 | 2/28 | 21.5 (12-38) | 3/29 |
| HPV - | 24/15 | 7/17 | 0/24 | 15 (7-27) | 14/24 |
| p | 0.002 | 0.06 | Ns | Ns | 0.01 |
| OR (95% CI) | 9.3 (1.7-66) | 0.17 (0.2-1.08) | 0.17 (0.03-0.7) | ||
| Total | 94/26 | 28/66 | 7/96 | 22 (10-42.5) | 42/77 |
| HPV + | 44/3 | 4/40 | 2/41 | 30.5 (13-54) | 5/42 |
| HPV - | 50/23 | 24/26 | 5/45 | 16 (8-42) | 37/35 |
| p | 0.001 | < 0.001 | Ns | 0.018 | < 0.001 |
| OR (95% CI) | 6.7 (1.7-30.4) | 0,1 (0.02-0.3) | 0.4 (0.05-2.7) | 0.11 (0.03-0.3) |
CR: complete response; LRR: loco-regional recurrence; DR: distant recurrence; DFS: disease-free survival; DSD: disease-specific death; Y: yes; N: no; IQR: interquartile range; Ns: not significant; OR: odds ratio; CI: confidence interval
a: data available only for subsets of cases.