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. 2019 Mar 26;10:198. doi: 10.3389/fphar.2019.00198

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Copyright © 2019 Martin, Talikka, Ivanov, Haziza, Hoeng and Peitsch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative reduction for each subject across arms and studies. The primary comparisons of interest are the relative decreases in the SA and THS arms and are all expected to show a decrease. In this context, following the intersection-union test method, an overall type I error rate of 0.05 is guaranteed without the need for a multiplicity adjustment. The average decrease is indicated under the boxes. “.” indicate a t-test p-value below 0.1, ^∗: below 0.05, ^∗∗: below 0.01, ^∗∗∗: below 0.001. D0: Day 0 (baseline); D6: Day 6; D91: Day 91. T-test refers to a one sample t-test on the baseline adjusted values (per subject).