Table I.
Characteristics of studies included in the review.
| All subjects | ||||||
|---|---|---|---|---|---|---|
| Author, year (ref.) | Country | Cases | Controls | Studied SNP | Association with CM risk | Association with other clinicopathological factors or disease progression |
| Hutchinson, 2000 (34) | UK | 316 | 108 | FokI | FF genotype - reduced CM risk | ttff genotype - thicker Breslow |
| TaqI | NA | |||||
| Halsall, 2004 (21) | UK | 174 | 80 | EcoRV | AA genotype - increased CM risk | AA genotype - thicker Breslow, metastasis development |
| Han, 2007 (35) | USA | 219 | 873 | FokI | NA | – |
| BsmI | ||||||
| Cdx2 | ||||||
| Santonocito, 2007 (29) | Italy | 112 | 101 | BsmI | bb genotype - increased CM risk | bb genotype - thicker Breslow |
| FokI | NA | NA | ||||
| EcoRV | ||||||
| Barroso, 2008 (30) | Spain | 283 | 245 | EcoRV | NA | – |
| FokI | ||||||
| TaqI | ||||||
| BglI | ||||||
| Li, 2008 (27) | USA | 805 | 841 | TaqI | t allele - reduced CM risk | – |
| BsmI | B allele - reduced CM risk | – | ||||
| FokI | f allele - increased CM risk | – | ||||
| Randerson-Moor, 2009 (28) | UK | 1028 | 402 | FokI | NA | – |
| TaqI | ||||||
| BsmI | ||||||
| ApaI | ||||||
| EcoRV | ||||||
| Cdx2 | ||||||
| Randerson-Moor, 2009 (28) | UK | 299 | 560 | FokI | F allele - increased CM risk | – |
| TaqI | NA | – | ||||
| BsmI | ||||||
| ApaI | ||||||
| EcoRV | ||||||
| Cdx2 | ||||||
| Gapska, 2009 (23) | Poland | 763 | 763 | FokI | NA | NA with Breslow |
| TaqI | ||||||
| BsmI | ||||||
| EcoRV | ||||||
| Halsall, 2009 (41) | USA | 176 | 80 | EcoRV | A allele - increased MM risk | A allele - thicker Breslow, metastasis development |
| Schäfer, 2012 (42) | Germany | 305 | 370 | TaqI | NA | NA with Breslow |
| ApaI | ||||||
| rs757343 | ||||||
| rs2107301 | ||||||
| Zeljic, 2014 (38) | Serbia | 117 | 122 | FokI | F allele - increased risk | NA with clinico-pathological characteristics |
| TaqI | t allele - increased risk | |||||
| ApaI | NA | |||||
| EcoRV | ||||||
| Mandelcorn-Monson, 2011 (36) | International | 1,138 multiple CM 2,151 single CM | – | FokI | NA | – |
| BsmI | BB genotype (+ highest UV exposure) multiple CM | |||||
| Orlow, 2012 (10) | International | 1,207 multiple CM 2,469 single CM | – | BsmI EcoRV rs10875712 rs4760674, rs7139166 rs11168287 | Increased multiple CM risk | – |
| rs7305032 rs7965281 | decreased multiple CM risk | |||||
| Orlow, 2016 (43) | International | 1,205 multiple CM 2,361 single CM | – | BsmI | – | B allele - protective for CM survival |
| TaqI | t allele - protective for CM survival | |||||
| Morgese, 2017 (45) | Italy | 88 | – | FokI | – | ff genotype - progression-free survival, histological regression, BRAF+ |
| TaqI | – | – | ||||
| BsmI | ||||||
| Orlow, 2018 (44) | International | 1,206 multiple CM 2,372 single CM | – | BsmI | – | B allele - decreased risk for CM death (if high UVB exposure) |
| TaqI | – | t allele - decreased risk for CM death (if high UVB exposure) | ||||
NA, not associated, ‘-’, not studied; CM, cutaneous melanoma.